cd D:\Program Files (x86)\Microsoft Visual Studio 10.0\VC\bin
vcvars32.bat
perl Configure VC-WIN32 no-asm --prefix=c:\openssl
ms\do_ms.bat
nmake -f ms\ntdll.mak
nmake -f ms\ntdll.mak test 通过进行下一步
nmake -f ms\ntdll.mak install
原文：http://www.cnblogs.com/boysbeer/p/4764963.html