相关：
GenyMotion自带VirtualBox
解决办法：
首先确认genymotion及virtualBox正确安装，然后右键点击启动程序选属性，在兼容性里选以兼容模式运行，同时勾选以管理员身份运行。
genymotion及virtualBox两个都要做，然后就可以了。
C:\Users\当前用户名\AppData\Local\Genymobile\genymotion.log
九月 6 21:02:01 [Genymotion] [Error] Output command: "VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code E_INVALIDARG (0x80070057) - One or more arguments are invalid (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start."
九月 6 21:02:01 [Genymotion] [Error] VBoxManage ("list", "hostinfo") returns 1
九月 6 21:02:01 [Genymotion] [Error] Output command: "VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code E_INVALIDARG (0x80070057) - One or more arguments are invalid (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start."
九月 6 21:02:02 [Genymotion] [Error] VBoxManage ("list", "hostinfo") returns 1
九月 6 21:02:02 [Genymotion] [Error] Output command: "VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code E_INVALIDARG (0x80070057) - One or more arguments are invalid (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start."
九月 6 21:02:03 [Genymotion] [Error] VBoxManage ("list", "hostinfo") returns 1
九月 6 21:02:03 [Genymotion] [Error] Output command: "VBoxManage.exe: error: Failed to create the VirtualBox object!
VBoxManage.exe: error: Code E_INVALIDARG (0x80070057) - One or more arguments are invalid (extended info not available)
VBoxManage.exe: error: Most likely, the VirtualBox COM server is not running or failed to start."
九月 6 21:02:03 [Genymotion] [Error] "Fail to load vboxmanage plugin from f:/Program Files/Genymobile/Genymotion/plugins/"
九月 6 21:02:03 [Genymotion] [Error] VM Engine failed to load
九月 6 21:02:03 [Genymotion] [Error] Unable to find VM Engine. Plugin loading aborted.
九月 6 21:02:03 [Genymotion] [Debug] [LogCollector] VM engine not available
http://www.imooc.com/qadetail/59986
原文：http://www.cnblogs.com/softidea/p/4787187.html