1、获取相对于控件的鼠标坐标；2、去掉控件的EventHandler的所有绑定事件；

Point x = imageBox1.PointToClient(Form1.MousePosition);
label2.Text = x.X.ToString() + " | " + x.Y.ToString();

public partial class Form1 : Form
{
        public Form1()
        {
            InitializeComponent();

            button1.Click += button1_Click;
            button1.Click += button1_Click2;
            button2.Click += button2_Click;
        }

        private void button1_Click(object sender, EventArgs e)
        {
            MessageBox.Show("Hello");
        }

        private void button1_Click2(object sender, EventArgs e)
        {
            MessageBox.Show("World");
        }

        private void button2_Click(object sender, EventArgs e)
        {
            RemoveClickEvent(button1);
        }

        private void RemoveClickEvent(Button b)
        {
            FieldInfo f1 = typeof(Control).GetField("EventClick", 
                BindingFlags.Static | BindingFlags.NonPublic);
            object obj = f1.GetValue(b);
            PropertyInfo pi = b.GetType().GetProperty("Events",  
                BindingFlags.NonPublic | BindingFlags.Instance);
            EventHandlerList list = (EventHandlerList)pi.GetValue(b, null);
            list.RemoveHandler(obj, list[obj]);
        }
    }
}