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<header></header>
<div class="content">
   <div class="left"></div>
   <div class="right"></div>
</div>
<footer></footer>

html,body{
   margin: 0;
   overflow:hidden;
}

header{
   height: 100px;

   position: fixed;
   top:0;
   left: 0;
   right: 0;
   background-color: lightgray;
}

.content{
   position: fixed;
   left: 0;
   right: 0;
   top: 100px;
   bottom: 100px;

   overflow: auto;
}

.content .left{
   width: 300px;
   height: 100%;
   position: fixed;
   left:0;
   top: 100px;
   bottom: 100px;
}

.content .right{
   height:1000px;
   margin-left:300px;
} 

footer{
   height: 100px;
   position: fixed;
   bottom:0;
   left:0;
   right:0;
   background-color: lightgray;
}