Predicts gene structure using similar protein sequences. GeneWise is heavily used by the Ensembl annotation system. It was developed from a principled combination of hidden Markov models (HMMs). GeneWise is highly accurate and can provide both accurate and complete gene structures when used with the correct evidence.
genewise使用通过genblasta得到的核酸序列和对应的蛋白质序列来预测gene structure
原文：https://www.cnblogs.com/yuanjingnan/p/12450048.html