这套教程源自Youtube,算得上比较完整的生物信息学领域的视频教程,授课内容完整清晰,专题化的讲座形式,细节讲解比国内的京师大学堂的Mooc教程好过10000倍.下面是视频的快速链接还有文档讲义哦,很好的东东,链接分享给国内的朋友们.

=课程主页:http://ocw.metu.edu.tr/course/view.php?id=37,

   Instructor: Tolga CAN

   Added: 18 November 2009

Topic outline

•  

  ---

  General

   

  INTRODUCTION TO BIOINFORMATICS

  
  

  •  

    Course OverviewPage
  •  

    National Center for Biotechnology Information, USA.URL
  •  

    Protein Data BankURL
•  
   

  ---

  Topic 1

  Introduction to Bioinformatics

  •  

    Lecture SlidesFile
  •  

    Week 1 - Lecture 1 [Video]File
•  
   

  ---

  Topic 2

  Introduction to biology, biological databases, and high-throughput data sources. Overview of bioinformatics problems.
  
  Pairwise sequence alignment algorithms: Dynamic programming

  •  

    Lecture SlidesFile
  •  

    Assignment 1File
  •  

    Reading: Bioinformatics - An Introduction for Computer ScientistsFile
  •  

    Reading: Cells and GenomesFile
  •  

    Reading: How Cells Read the Genome: From DNA to ProteinFile
  •  

    Reading: The Nucleic Acid WorldFile
  •  

    Reading: Producing And Analzying Sequence AlignmentsFile
  •  

    Week 2 - Lecture 1 [Video]File
  •  

    Week 2 - Lecture 2 [Video]File
  •  

    Week 3 - Lecture 1 [Video]File
  •  

    Week 3 - Lecture 2 [Video]File
  •  

    Week 4 - Lecture 1 [Video]File
  •  

    Week 4 - Lecture 2 [Video]File
•  
   

  ---

  Topic 3

  Statistical significance of alignments - Part I
  
  Statistical significance of alignments - Part II

  •  

    Lecture SlidesFile
  •  

    Reading: Pairwise Sequence AlignmentFile
  •  

    Week 5 - Lecture 1 [Video]File
  •  

    Week 5 - Lecture 2 [Video]File
  •  

    Week 5 - Lecture 3 [Video]File
•  
   

  ---

  Topic 4

  Suffix Trees, Suffix Arrays

  •  

    Lecture SlidesFile
  •  

    Week 6 - Lecture 1 [Video]File
  •  

    Week 6 - Lecture 2 [Video]File
•  
   

  ---

  Topic 5

  Patterns, Profiles, and Multiple Alignments

  •  

    Lecture SlidesFile
  •  

    Assignment 2File
  •  

    Week 6 - Lecture 3 [Video]File
•  

  ---

   

  Topic 6

  Hidden Markov Models
  
  Week 5 Lecture Slides Continued

  •  

    Week 7 - Lecture 1 [Video]File
  •  

    Week 7 - Lecture 2 [Video]File
  •  

    Week 7 - Lecture 3 [Video]File
•  

  ---

  Topic 7

  Multiple Sequence Alignment Algorithms
  
  Week 5 Lecture Slides Continued

  •  

    Week 8 - Lecture 1 [Video]File
  •  

    Week 8 - Lecture 2 [Video]File
  •  

    Week 8 - Lecture 3 [Video]File
•  
   

  ---

  Topic 8

  Midterm Review and Midterm Exam

  •  

    Midterm ExamFile
  •  

    Midterm KeyFile
  •  

    
    Phylogenetic trees
  •  

    Lecture SlidesFile
•  
   

  ---

  Topic 9

  Introduction to protein structures
  
  Structure Prediction

  •  

    Lecture SlidesFile
  •  

    Assignment 3 for Computer Engineering MajorsFile
  •  

    Assignment 3 for Biology or Genetics MajorsFile
  •  

     Week 9 - Lecture 1 [Video]File
  •  

     Week 9 - Lecture 2 [Video]File
  •  

     Week 9 - Lecture 3 [Video]File
  •  

     Week 9 - Lecture 4 [Video]File
•  
   

  ---

  Topic 10

  Protein Structure Prediction (continued)

  •  

     Week 10 - Lecture 1 [Video]File
  •  

     Week 10 - Lecture 2 [Video]File
  •  

     Week 10 - Lecture 3 [Video]File
•  

  ---

   

  Topic 11

  Protein Structure Prediction (continued)

  •  

    Week 11 - Lecture 1 [Video]File
  •  

    Week 11 - Lecture 2 [Video]File
  •  

    Week 11 - Lecture 3 [Video]File
•  
   

  ---

  Topic 12

  Structural Alignment of Proteins
  (lecture notes continued)

  •  

    Week 12 - Lecture 1 [Video]File
  •  

    Week 12 - Lecture 2 [Video]File
  •  

    Week 12 - Lecture 3 [Video]File
•  
   

  ---

  Topic 13

  Microarray data normalization, analysis
  
  Clustering techniques

  •  

    Lecture SlidesFile
  •  

    K-means DemoFile
  •  

    Self Organizing Maps DemoFile
  •  

    Reading: Microarrays Intro Paper - 1File
  •  

    Reading: Microarrays Intro Paper - 2File
  •  

    Reading: Microarrays Intro Paper - 3File
  •  

    Week 13 - Lecture 1 [Video]File
  •  

    Week 13 - Lecture 2 [Video]File
•  

  ---

  Topic 14

  Introduction to Systems Biology
  
  Gene regulatory networks

  •  

    Lecture SlidesFile
  •  

    Assignment 4File
  •  

    Dataset for Assignment 4File
  •  

    Week 14 - Lecture 1 [Video]File
•  
   

  ---

  Topic 15

  Construction and Analysis of protein networks:
  Monte Carlo Sampling, Random Walks on Graphs

  •  

    Lecture SlidesFile
  •  

    Likelihood Computation ExampleFile
  •  

    Week 15 - Lecture 1 [Video]File
  •  

    Week 15 - Lecture 2 [Video]File
  •  

    
    Final review